| 8-Jan-10 | Officer | FRIEDMAN STEVEN M. | Sale at $10.90 per share. | D | 22,000 |
| 24-Sep-09 | Director | 14159 CAPITAL (GP), LLC | Acquisition (Non Open Market) at $6.75 per share. | I | 101,506 |
| 24-Sep-09 | Director | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC | Acquisition (Non Open Market) at $6.75 per share. | I | 1,848,200 |
| 24-Sep-09 | Director | BAKER / TISCH CAPITAL (GP), LLC | Acquisition (Non Open Market) at $6.75 per share. | I | 50,294 |
| 9-Mar-09 | Officer | FRIEDMAN PAUL A | Purchase at $2.10 per share. | D | 9,400 |
| 6-Mar-09 | Officer | FRIEDMAN PAUL A | Purchase at $2.10 per share. | D | 10,600 |
| 5-Mar-09 | Officer | FRIEDMAN PAUL A | Purchase at $2.20 per share. | D | 8,840 |
| 5-Mar-09 | Director | 14159 CAPITAL (GP), LLC | Purchase at $2.16 per share. | I | 312 |
| 5-Mar-09 | Director | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC | Purchase at $2.16 per share. | I | 11,232 |
| 5-Mar-09 | Director | BAKER / TISCH CAPITAL (GP), LLC | Purchase at $2.16 per share. | I | 64 |
| 5-Mar-09 | Director | BAKER BROS. CAPITAL (GP), LLC | Purchase at $2.16 per share. | I | 5 |
| 5-Mar-09 | Director | BAKER BIOTECH CAPITAL (GP), LLC | Purchase at $2.16 per share. | I | 1,248 |
| 3-Mar-09 | Officer | FRIEDMAN PAUL A | Purchase at $2.20 per share. | D | 11,160 |
| 3-Mar-09 | Director | 14159 CAPITAL (GP), LLC | Purchase at $2.14 per share. | I | 264 |
| 3-Mar-09 | Director | BAKER BROTHERS LIFE SCIENCES CAPITAL (GP), LLC | Purchase at $2.14 per share. | I | 9,524 |