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CureVac Shares Pop After Encouraging Update From COVID-19, Flu mRNA Vaccine Programs

Vandana Singh
·2 分鐘文章

  • CureVac N.V. (NASDAQ: CVAC) announced extended preliminary data from ongoing Phase 1 programs in COVID-19 and seasonal flu conducted in collaboration with GSK plc (NYSE: GSK). The newly reported data focus on older adult age groups.

  • COVID-19 Program

  • Newly reported immunogenicity data from CV0501 in older adults (age ≥65) are based on the fully recruited dose groups of 12, 25 and 50µg, consisting of 10 subjects per dose.

  • On day 29 at the 12µg dose level, CV0501 generated a ratio of post-boost to pre-boost serum neutralizing titers against BA.1 of 13.3.

  • While CV0501 encodes the Omicron BA.1 variant, a Phase 2 study, expected to start in 2023, will assess monovalent and/or bivalent vaccine candidates designed to target clinically relevant variants.

  • Related: Fighting Omicron: This Covid Vaccine Candidate Is Going After The Dangerous Mutation.

  • Seasonal Flu Program

  • A single dose of Flu-SV-mRNA (dose level undisclosed) was assessed for safety and reactogenicity in older adults (age 60-80) and was observed to be safe and well tolerated with no grade 3 adverse events in the 32 subjects who were administered the mRNA construct.

  • Adjusted geometric mean hemagglutinin inhibition antibody titers elicited by Flu-SV-mRNA in older adults were approximately 2.3 times those elicited by the licensed vaccine comparator.

  • In the same age group, the percentage of subjects achieving seroconversion was 89.7% for Flu-SV-mRNA and 56.2% for the licensed flu vaccine comparator.

  • The vaccine candidate for future clinical development is expected to target all four flu virus strains currently recommended by the WHO for influenza vaccines.

  • A Phase 1/2 study for multivalent vaccine candidates is expected to start around mid-2023.

  • Price Action: CVAC shares are up 8.82% at $12.40 on the last check Monday.

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This article originally appeared on Benzinga.com

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